Host Protease Activity on Bacterial Pathogens Promotes Complement and Antibiotic-Directed Killing

Host Protease Activity on Bacterial Pathogens Promotes Complement and Antibiotic-Directed Killing

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Our understanding of how the host immune system thwarts bacterial evasive mechanisms remains incomplete.Here, we show that host protease neutrophil elastase acts on Acinetobacter baumannii and Pseudomonas pet calming peanut butter aeruginosa to destroy factors that prevent serum-associated, complement-directed killing.The protease activity also enhances bacterial susceptibility to antibiotics in sera.These findings implicate a new paradigm where host protease activity on bacteria acts combinatorially with iphone 14 price san francisco the host complement system and antibiotics to defeat bacterial pathogens.